REVIEW ARTIKEL : BERBAGAI AKTIVITAS FARMAKOLOGI DARI SENYAWA KITOSAN

Anisa Marieta, Ida Musfiroh

Abstrak


Kitosan adalah salah satu senyawa dari turunan kitin, dan banyak dihasilkan oleh hewan seperti  cangkang eksoskeleton artropoda (kepiting, udang, lobster) maupun jamur. Kitosan dapat terbentuk dengan pengurangan gugus asetil dengan adanya proses deasetilasi. Keberadaan kitin sangat berlimpah di alam, dan menurut beberapa penelitian ternyata kitosan memiliki berbagai aktivitas farmakologi seperti sebagai antibakteri, antioksidan, antihiperglikemik, antimalarial, antiulcer, antifungal, dan antitoxoplasma. Dengan begitu dapat diketahui bahwa kitin memiliki banyak manfaat bagi kelangsungan hidup manusia.

Kata kunci : Kitosan, gugus asetil, aktivitas farmakologi.


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Referensi


Fadli, et al.2015. Pengaruh Rasio Massa Kitin/NaOH dan Waktu Reaksi Terhadap Karakteristik Kitosan yang Disintesis dari Limbah Industri Udang Kering. Jurnal Sains Materi Indonesia. Vol.18(2);61-67.

Sarwono, R. 2010. Pemanfaatan Kitin/ Kitosan Sebagai Bahan Anti Mikroba. JKTI, 12(1).

Yuliusman & Adelina P.W. 2010, Pemanfaatan Kitosan dari Cangkang Rajungan Pada proses Adsorpsi Logam Nikel dari larutan NiSO4, Seminar Rekayasa Kimia dan Proses, ISSN: 1411-4216.

Goy, et al. 2009. A Review of the Antimicrobiacl Activity of Chitosan. Polimores: Ciencia e Technologia. Vol 9(3):241-247.

Mohammedi, Z. 2017. Chitosan and Chitosan Oligosaccharides: Applications in Medicine, Agriculture and Biotechnology. International Journal of Bioorganic Chemistry 2(3): 102-106.

Kong, M., Chen, X.G., Xing.K., Park.H.J. 2010. Antimicrobial properties of chitosan and mode action: A state of the art review. International Journal of Food Microbiology, 144(1):51-63.

S. Batelho da Silva, et al. 2018. Water Soluble chitosan derivatives and pH-responsive hydrogels by selective C-6 oxidation mediated by TEMPO-laccase redox system. Carbohydrate Polymers 186:299-309.

Werdhasari, A. 2014. Peran Antioksidan bagi Kesehatan. Jurnal Biotek Medisiana Indonesia . Vol.3(2): 59-68.

Xie, W., Peixin Xu and Qing Liu. 2001. Antioxidant Activity of Water-Soluble Chitosan Derivatives. Bioorg. Med. Chem. Lett. 11: 1699–1701.

Kong, S. et al. 2018. Anti-Aging Effect of Chitosan Oligosaccharide on D-Galactose-Induce Subacute Aging in mice. Mar. Drugs. Vol 16; 181.

Nehad M. Gumgumjee et al. 2018. Antioxidant and Antibacterial Activity of Chitin, Chitosan and Shrimp Shells from Red Sea for Pharmaceutical Uses. International Journal of Pharmaceutical Research & Allied Sciences, Vol 7(1):1-8.

Benhabils, et al. 2012. Antibacterial activity of chitin, chitosan and its oligomers prepared from shrimp shell waste. Food Hydrocolloids. Vol 29:48-56.

Tareq, A. et al. 2013. Comparative Study of Antibacterial Activity of Chitin and Chemically Treated Chitosan Prepared from Shrimp (Macrobrachium Rosenbergii) Shell Waste. Journal of Virology & Microbiology.

Yao,H. Shan-Ye,H H, dan Meng-Tsan, C. 2008. A comparative study on hypoglycemic and hypocholesterolemic effects of high and low molecular weight chitosan in streptozotocin-induced diabetic rats. Food and Chemical Toxicology .46:1525–1534.

Prabu dan Naratajhan. 2012. Antihyperglicemic Effect of Chitosan Of Podophthalmus Vigil in Streptozotocin-induced Diabetic Rats. IJSPR.Vol 4(1).

Alburquenque, C., et al. 2010. Antifungal activity of low molecular weight chitosan against clinical isolates of Candida spp. Medical Mycology Vol 48:1018–1023.

Shih, et al. 2019. A Potential Antifungal Effect of Chitosan Against Candida albicans Is Mediated via the Inhibition of SAGA Complex Component Expression and the Subsequent Alteration of Cell Surface Integrity. Frontiers in Microbiology Vol 10 (502).

Akila, R. M., dan Priya N. 2012. Screening of gastric antiulcer potential of chitosan extracted from white button mushroom wastes in wistar rats. Adv. Appl. Sci. Res. 3(5):3160-3164.

Olivier B and Jean YR. 2007. Glucosamine and chondroit in sulfate as therapeutic agents for ulcer and hip osteo-arthritis. Drugs and Aging. 24(7): 573-580.

Dubey JP. 2010. Toxoplasmosis of Animals and Humans. 2nd ed. New York: Boca Raton.

Teimouri, et al. 2018. anti-Toxoplasma activity of various molecular weights and concentrations of chitosan nanoparticles on tachyzoites of rh strain. International Journal of Nanomedicine Vol 13:1341-1351.

Ramazani A, Zakeri S, Sardari S, Khodakarim N, Dinparas Djadidt N. 2010. In vitro and in vivo antimalarial activity of Boerhavia elegans and Solanum surattense. Malar J 9: 124.

Teimouri, et al. 2016. efficacy of low molecular weight chitosan against Plasmodium berghei infection in mice. J Vector Borne 53: 312–316.




DOI: https://doi.org/10.24198/jf.v17i2.21866

DOI (PDF): https://doi.org/10.24198/jf.v17i2.21866.g11622

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